A vitamin D level of 25 ng/mL is considered low. Low levels of vitamin D can occur from low dietary intake, limited exposure to sunlight, poor kidney function resulting in impaired conversion of 25(OH)D, or inadequate vitamin D absorption.
Low vitamin D levels can negatively affect your health and put you at increased risk for, and severity of COVID-19, diabetes, and cancer. Having low levels of vitamin D may also increase your risk for certain autoimmune and neurodegenerative diseases like multiple sclerosis and Alzheimer’s.
Diet low in vitamin D
Older age (partly due to a decline in the skin’s ability to synthesize vitamin D with age)
Living in cold or northern climates (those who live above 37°N latitude cannot synthesize vitamin D year-round)
Limited sun exposure (such as those who spend the majority of their time indoors or are covered when outside)
Pregnancy and breastfeeding
Cystic fibrosis, Crohn's, celiac, kidney, and liver disease, or other conditions that interfere with vitamin D absorption or synthesis
Obesity (larger amounts of subcutaneous fat sequester more of the vitamin)
Gastric bypass surgery
To improve vitamin D levels:
Increase consumption of vitamin D-rich foods like salmon, herring, canned tuna, eggs (with the yolk), and fortified foods like milk, yogurt, and breakfast cereals
Get 10–30 minutes of unprotected midday sunlight most days
Take a vitamin D supplement. How much you should take will depend on your level of deficiency. For a level of 25, you will likely need to take 5,000 IU daily for several months to significantly improve your vitamin D status.
If levels do not improve after 3 months, review your supplements with an expert or talk to your doctor.
If you are vitamin D deficient, a daily supplement is typically needed to get levels into the optimal range (40-80 ng/mL) over time.
For levels of 25 ng/mL, talk to your healthcare provider. Daily supplementation of vitamin D3 (cholecalciferol) should be considered to achieve adequate body stores.
National Institutes of Health. (2021, March 26). Office of Dietary Supplements - Vitamin D. National Institutes of Health – Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
Alshahrani, F., & Aljohani, N. (2013). Vitamin D: deficiency, sufficiency, and toxicity. Nutrients, 5(9), 3605–3616. https://doi.org/10.3390/nu5093605
Holick M. F. (2009). Vitamin D status: measurement, interpretation, and clinical application. Annals of epidemiology, 19(2), 73–78. https://doi.org/10.1016/j.annepidem.2007.12.001
Demir, M., Demir, F., & Aygun, H. (2021). Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease. Journal of medical virology, 93(5), 2992–2999. https://doi.org/10.1002/jmv.26832
Kayaniyil, S., Vieth, R., Retnakaran, R., Knight, J. A., Qi, Y., Gerstein, H. C., Perkins, B. A., Harris, S. B., Zinman, B., & Hanley, A. J. (2010). Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes care, 33(6), 1379–1381. https://doi.org/10.2337/dc09-2321
Examine.com. (2019, April). A D-fence against cancer? https://examine.com/members/deep-dives/article/a-d-fence-against-cancer/
Yang, C. Y., Leung, P. S., Adamopoulos, I. E., & Gershwin, M. E. (2013). The implication of vitamin D and autoimmunity: a comprehensive review. Clinical reviews in allergy & immunology, 45(2), 217–226. https://doi.org/10.1007/s12016-013-8361-3