A homocysteine level of 10 is considered elevated. Elevated levels of homocysteine (an amino acid in your blood) are often related to a B vitamin deficiency. High homocysteine is associated with an increased risk of blood clots, heart attacks, heart disease, stroke, dementia, and osteoporosis [ 1
Elevated homocysteine typically does not cause any symptoms in adults; however, if it’s related to a vitamin B deficiency, you may experience the following symptoms:
Pale skin
Fatigue
Weakness
Tingling hands, arms, legs, or feet
Mouth sores
Dizziness
Weakness
Changes in mood
Swelling of the tongue (folate deficiency)
Anemia
Learn more about homocysteine homocysteine levels
Certain factors and health conditions can increase your risk for elevated homocysteine levels, including [ 1 2
Older age (homocysteine levels can increase as you get older)
Menopause
Being male (men usually have higher homocysteine levels than women)
Drug and tobacco use
Drinking 4 or more cups of coffee a day
Excessive alcohol consumption
Deficiencies in vitamins B12, B6, or folate
Kidney or thyroid problems
Cancer
Psoriasis
Diabetes
Heart disease
Certain variations of the MTHFR gene
Rare inherited diseases, including homocystinuria
Increasing your intake of folic acid (folate), B6, and B12 from foods may help lower your homocysteine level naturally. Some good dietary sources include:
Folate: Fruits, green leafy vegetables, fortified bread and breakfast cereals, lentils, chickpeas, beans, and asparagus
Vitamin B12
Vitamin B6: Tuna, beef, fortified cereals, milk, chickpeas, chicken, and eggs
Quitting smoking, limiting your alcohol intake
In addition to making these diet and lifestyle changes, your healthcare provider may recommend certain medications or supplements to help lower your homocysteine level.
Levothyroxine: For high homocysteine levels caused by hypothyroidism, levothyroxine may be prescribed alongside a folic acid supplement to improve thyroid function and lower homocysteine levels [ 3
Betaine: Also known as betaine anhydrous, or trimethylglycine (TMG), betaine is often prescribed to individuals with homocystinuria along with B vitamin supplements to help control homocysteine levels [ 4
Vitamin B supplements are used to treat high homocysteine caused by a B vitamin deficiency. The common dosage to treat low vitamin B is [ 2
50 mg/day of vitamin B6
1,000 µg (1 mg)/day of vitamin B12
2,400 µg (2.4 mg)/day of folic acid, split into three doses
If you have elevated homocysteine or suspect you may have a B vitamin deficiency, you may want to give Elo Health here
Homocysteine: Levels, Tests, High Homocysteine Levels. (2018, December 2). Cleveland Clinic. Retrieved June 8, 2022, from https://my.clevelandclinic.org/health/articles/21527-homocysteine
Varga, E. A., Sturm, A. C., Misita, C. P., & Moll, S. (2005). Homocysteine and MTHFR Mutations. Circulation, 111(19). https://doi.org/10.1161/01.cir.0000165142.37711.e7
Ziaee, A., Hajibagher Tehrani, N., Hosseinkhani, Z., Kazemifar, A., Javadi, A., & Karimzadeh, T. (2012). Effects of folic acid plus levothyroxine on serum homocysteine level in hypothyroidism. Caspian journal of internal medicine, 3(2), 417–420. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861905/
Betaine: MedlinePlus Drug Information. (2016, September 15). Retrieved October 3, 2022, from https://medlineplus.gov/druginfo/meds/a608012.html