If you’ve ever felt butterflies in your stomach or felt nauseous when stressed, you’ve experienced the physical connection between your gut and brain. However, this connection does far more than give physical sensation to your emotions, as researchers suggest your gut exerts a powerful influence over your mood and mental health.

Before we dig into the science surrounding the microbiome, let’s first understand the gut brain connection, and how you can restore gut health.

Gut brain connection

Your gut and brain communicate via a bidirectional connection called the gut brain axis. The gut brain axis is a complex communication network that links the nervous system in your gut (known as the enteric nervous system, or ENS) with your brain (central nervous system). 

The ENS consists of a web of over 100 million neurons lining the gastrointestinal (GI) tract from the esophagus to the rectum. It’s directly connected to the brain by the vagus nerve, which has two branches: one that sends signals from the gut to the brain and the other from the brain to the gut.

The gut and brain also communicate via endocrine, immune, and metabolic pathways [

1

]. Hormones, like leptin and ghrelin, communicate hunger and satiety signals to your brain, whereas immune cells regulate inflammatory responses and immune balance in a bidirectional relationship [

2

]. 

Your gut microbiome—the collection of microorganisms that live in your intestines—is also deeply involved in how your brain and gut communicate [

1

]. These microscopic bugs can communicate with the brain in numerous ways [

3

]:

• They secrete substances, like neurotransmitters, which enter the bloodstream and affect the brain. 

• Your gut microbes prompt the cells lining your intestines to stimulate the vagus nerve.

• They activate hormone-producing cells in the gut that send hormones throughout the body, affecting the brain. 

• Your gut microbes influence immune cells and inflammation, also affecting the brain.

The connection between your gut and mental health

Studies show your gut microbes affect the emotional and cognitive centers of the brain, influencing your mood, emotional regulation, and even your risk for mood disorders, including anxiety and depression [

1

]. 

Let’s take a closer look at how the microbiome affects mental health.

Neurotransmitters and your mood. 

Good gut bacteria produce hormone-like chemicals that make their way to the brain via the bloodstream [

4

]. Let’s briefly explore some of these.

• Serotonin. This neurotransmitter plays a critical role in mood regulation and mediates factors like satisfaction, happiness, and optimism. Interestingly, more than 90% of serotonin is manufactured in the gut, some directly by good gut bacteria [

  5

  ]. Research shows that higher levels in adults are associated with positive mood, while low levels may contribute to poor memory and lower mood [

  6

  ,

  7

  ].

• Dopamine and GABA. Dopamine is a key regulator of decision-making, attention, memory, motivation, and reward, whereas gamma-aminobutyric acid (GABA) helps control feelings of fear and anxiety [

  4

  ,

  8

  ,

  9

  ]. 

• Butyrate. Butyrate is a short-chain fatty acid and potent anti-inflammatory compound, and serves as the main energy source for your colon cells. It’s also been shown to reduce anxiety and depression and improve quality of life [

  10

  ,

  11

  ]. Other evidence suggests butyrate may provide other health benefits, too, including supporting your immune system, reducing inflammation, and preventing diseases like cancer [

  12

  ].

Interestingly, it’s been found that certain species of gut bacteria (Coprococcus and Dialister) were missing in people with depression, but not from those with a reported high quality of life [

11

]. Coprococcus was also found to have a biological pathway associated with dopamine, so it’s possible the absence of this bacteria may contribute to depression [

11

].

Stress, poor diet, or antibiotics.

Studies have found that unfavorable changes in the microbiome might tip the production of neurotransmitters and other chemicals in a way that could hurt your mental health. Here’s how stress, poor diet, or antibiotics can have a direct impact on your brain. 

• Stress. Studies suggest that stress and depression can alter your microbiome through hormones, inflammation, and changes in the ENS [

  14

  ]. 

• Poor diet. Dysbiosis (an imbalanced microbiome) and inflammation of the gut are linked to mental illnesses, including anxiety and depression [

  13

  ]. Research shows high intakes of fat (especially saturated fat), protein (particularly from red and processed meat), sugar, and food additives, which are common in the Western diet, can alter the balance of good and bad bacteria in your gut [

  21

  ,

  22

  ,

  23

  ].

• Antibiotics. Antibiotics kill bacteria, which can wreak havoc on your microbiome. Research shows even a single week-long course of antibiotics can reduce the diversity of microbes in the gut and promote the overgrowth of certain “bad” bacteria, having a significant and lasting impact on microbiome balance and gut health [

  24

  ].

Benefits of probiotics on mental health 

Several studies have shown probiotics can have a beneficial effect on mood and alleviate symptoms of depression, stress, and anxiety [

13

,

15

,

16

].  

Current findings suggest the best probiotics for mood and anxiety include B bifidum, B lactis, L acidophilus, L brevis, L casei, L salivarius, and L lactis [

1

]. Lactobacillus and Bifidobacterium have also been shown to reduce levels of cortisol and psychological improvements similar to participants given Diazepam, a commonly used anti-anxiety medication [

18

]. Furthermore, people have reported an overall happier mood after 3 weeks of taking Bifidobacteria [

17

]. 

Other studies have also found that probiotic therapy and fecal transplants might reduce certain depressive symptoms [

19

,

20

].

While there are no specific dosage guidelines for probiotics, one study found that people who took 5 billion colony-forming units (CFUs) per day of a multi-strain probiotic for four weeks experienced improvements in sad moods and other depressive symptoms compared to those given a placebo [

19

]. 

3 ways to improve gut health and your mood

The best and easiest way to support a healthy gut and a healthy mind is by keeping your microbiome healthy. Here are three ways to improve gut health.

1. Fill up on fiber-rich foods. 

Eating a diet high in fiber feeds your good bacteria and can be an accessible and affordable way to help your microbiome flourish. 

For the most benefit, it’s recommended to eat 30-40 grams of fiber/day from a variety of fiber-rich plants (like whole grains, fruits, vegetables, beans, and legumes) and avoid highly processed foods as much as possible.

2. Prioritize probiotics.

You can obtain probiotics from certain foods and supplements. 

Good food sources

include fermented foods like yogurt, kefir, sauerkraut, kimchi, tempeh, and cottage cheese.

Probiotic supplements

are also a good way to incorporate more good bacteria into your gut. 

3. Find healthy ways to cope with stress.

Stress management techniques like meditation, yoga, listening to music, and getting regular exercise and adequate sleep can all help reduce stress levels and support a healthy, well-balanced microbiome.

Summary

Research investigating the complex gut-brain connection shows your gut exerts powerful influence over your mood and mental health. Much of this connection is attributed to the trillions of microorganisms that make up your microbiome, which affect the emotional and cognitive centers of the brain and even your risk for mood disorders like anxiety and depression. A growing body of research shows a healthy gut microbiome can be beneficial for your mood, and that probiotics may also be an effective way to support mental health and alleviate symptoms of anxiety and depression. 

You can support a healthy gut by eating plenty of fiber-rich foods, regularly consuming probiotics, and incorporating stress management techniques.

Disclaimer: The text, images, videos, and other media on this page are provided for informational purposes only and are not intended to treat, diagnose, or replace personalized medical care.